Wenkou basin is abundant in gypsum resource with good quality, but complicated in its hydrology induced by structure. This paper, based on the experience in exploring gypsum deposit in adjacent areas, applies the comprehensive methods to explore the Xinzhuang gypsum deposit which incorporate geophysical, drilling, and hydrological drilling, and proves the structures and aquifers within ore blocks. The geophysical methods play a key role, including 2D seismic and PE. Drilling and hydrological drilling demonstrate further the geophysical achievements.