This paper uses OLS to analyze their industrial growth and factors in China's four areas where percentage of resource investment to fixed asset investment seats on top, aiming at finding out the reasons of industrial growth differentiation in resource-based areas. This paper selects resources investment, manufacturing investment, investment and industrial structure in resource industry and manufacturing, employment rate and structure as variables, which are rarely covered by the current research, to analyze their economic growth differentiation from perspective of structural variance. The main reasons lie in investment structure, the proportion of resource industry to manufacturing in added investment, rather than in difference in resource investment, nor in deficiency in manufacturing investment. This paper presents suggestions on optimizing investment structure and revising industrial and employment structures so as to improve the contribution of investment size and structure in resource industry and manufacturing to industrial growth.