Big accidents happening at mines make huge loss to people's lives and properties, lead to kickback, and heavily restrict the mine's development. The safety management in mine enterprises becomes a big issue which catches governmental and social attention. This paper analyzes the root causes of casualty accidents, and establishes the safety culture system to enhance safety management, and presents suggestions in six aspects constructing mine enterprises safety culture, safety consciousness, training, family involvement, accident report, safety investment and safety rewards and punishment system.