The urban cluster in Shandong peninsula as a leading area in economic development in Shandong province is still in the beginning stage of urban cluster development; however, it is one of Chinese vital urban clusters with Qingdao and Ji’nan as two centers, which grows in a form of point to line. This paper, based on the systematism, openness and sustainable development, attempts to establish an urban cluster spatial structural layout for Shandong peninsula in the 21st century with two centers and four axes.