Tudaban Pb-Zn deposit is located in the transition between Qilian orogen and Dunhuang block, and hosted at the 2nd member of the 2nd formation, Archean-Proterozoic Dunhuang group. The structure and strata are two key factors in the formation of deposit. The EW-orientated fault zone is a major control of mineralization. Pb's concentration is closely related to Dunhuang group, Zn also has been overlapped by post granite hydrotherm. The import ore-finding indexes include the 2nd member of the 2nd formation, Dunhuang group, altered fracture zone, yellow jarosite zone on surface and gossan.