This paper gives a brief introduction to the exploration of global uranium resources, and analyzes the explored reserve and potential of uranium, production, consumption and supply of nuclear fuel, and the guarantee of uranium resources to the world’s nuclear power. According to China’s demands of uranium resources to develop the nuclear power, the paper presents a strategy to increase the exploration of uranium resources to guarantee the nuclear power development, including five aspects: to enhance input on the exploration based on the existing situation so as to meet the internal demands of uranium resources; to reform the management system of uranium resources to let competent units involve in uranium exploration and development; to develop the foreign uranium resources and to use the exported uranium; to increase the utilization rate of natural uranium by means of decreasing the concentrate in the isotope wastes; and to develop the new nuclear power technology and to improve the comprehensive utilization of uranium resources.