It is popular, both in academy and government, to study the industrial transformation and upgrade of resource-exhausted cities, whose universal adaptability, however, is weakened by a regional economic development and resource abundance. A singular city is selected as target. This paper, based on Hubei's seven resource-exhausted cities, Huangshi, Ezhou, Qianjiang, Daye, Yidu, Zhongxiang and Songzi, analyzes their industry, challenges and industrial transformation direction and path, and presents suggestions for government and enterprises to explore new paths of industrial transformation and upgrading from structural adjustment, financing, talent, environmental protection, industrial convergence and government's functions.