This paper, based on an integration of urban and rural areas, taking the cities, towns and villages as one whole region, studies the influence factors to regional land intensive use from nature, society, economy and human’s activities, which is basis to study the drives. The natural factors include geology, terrain, climate and environment. The social factors include urbanization level, popular density, technical level and location. The economic factors include economic level, industrial structure, industrial concentration and land price. The human’s activities include policies, macroscopic controls and culture and customs. The natural factors are the constraints, the social and economic factors are accelerates and the human’s factors are controls. All factors play mutually to promote a regional land intensive use.