Tangshan gold mine is the only independent, miniature fine disseminated gold deposit found in Jiangsu Province. Followed by 1∶〖KG-*2〗200000, 1∶〖KG-*2〗50000 database of natural placer mineral survey in Tangshan gold district, and combined with the assemblage characteristics of minerals in deposit, we chose limonite, pyrite, arsenic minerals (like realgar, orpiment and arsenopyrite), cinnabar, native silver, lead minerals (including natural lead, galena and cerussite), sphalerite, native gold, copper minerals (such as chalcopyrite, bornite, azurite and malachite), barite and so on as the major typomorphic minerals. Through ZSAPS2.0 software and GIS platform, this paper finally delineates natural placer mineral combinaton anomalies, and finds out that pyrite and limonite are the direct indicative minerals, and native gold, sphalerite, cinnabar, arsenopyrite, barite are the secondary indicative minerals of Tangshan gold mine. Considering prospecting signs, we establish Tangshan gold mine geologicalnatural placer prospecting criteria, which provides some reference for indepth evaluation of Tangshan gold prospecting potential.