A constraint in resources and environment requires a new industrialization, during which a leading industry must be correctly selected to direct development of other related industries and then form a industrial cluster. This paper, based on Xinjiang's situation and combined with connotation, correlation, potential and advantages, selects 22 indexes to form a index system, and determines, by means of Weaver-Thomas model, Xinjiang's leading industry and cultivating industry. Xinjiang's industrialization on leading industries shall be focused on petroleum, power, chemicals, black metallic mining, processing and metallurgy, and on cultivating industries on manufacturing, non-ferrous metallic mining and processing and metallurgy, plastics, industrial mining and processing, natural gas and equipments. During development of leading industries, in accordance with a principal “reduced quantity, recycled and renewed”, circular economic chain must be established to promote a leading industry cluster and featured regional leading industries and featured industries.